Hemophilia Genetic Blood

Hemophilia Genetic Blood Hemophilia is a sex-linked genetic disorder that prevents your blood from clotting normally. The blood may clot very little but can easily dislodge. Patients with the disease can bleed for days. It is located on your X sex chromosome and is found in males of all races and ethnic groups. A female can have Hemophilia, but it is extremely rare and uncommon. Most people who had Hemophilia in the 1980s were also diagnosed with HIV. There are two types of Hemophilia; type A and type B. Type A Hemophilia is caused by a lack or shortage of clotting factor eight. 1 out of every 5,000 male babies are born with type A. Type B is caused by a shortage of clotting factor 9. It is less common than type A and is found in 1 out of 30,000 male babies. Although males are inherited with the disease, females carry it. Females may get a genetic test to see if they carry the disease. Hemophilia can be mild, moderate, or severe. If you have a mild case, clotting factor 8 or 9 is 5% normal or greater. In a moderate case, clotting factor 8 or 9 is 1% to 5% normal. In a severe case, clotting factor 8 or 9 is less than 1% of normal. Also in a severe case, bleeding may happen more than once a week for no reason. A patient with severe Hemophilia is usually diagnosed during their first year of life. The percentage of a clotting factor will most likely stay the same throughout a persons life. There is no actual cure for Hemophilia just yet, but people with the disease can inject themselves with the clotting factors 8 and 9 to stop their bleeding. A treatment for the disease can depend on the type of Hemophilia the person has. A persons immune system can attack the clotting factors that were injected. If this happens, then extra treatment may be needed. There is no way to prevent a child from getting Hemophilia. A genetic counselor can tell how severe the Hemophilia may be and the risk for it. Some symptoms of Hemophilia can be bleeding into the joints, bleeding in soft tissues and muscles, or bleeding in the mouth. Symptoms may become less severe as a child gets older. It doesnt mean that their case is any less severe, but they learn to avoid things that can lead them to bleeding. Most bleeding is caused by an injury or a twist of a joint. Most people with Hemophilia live a normal life span if they can control their bleeding with injecting themselves. Hemophilia is caused when a person has a mutation in of their clotting genes. Almost 90% of patients have a mutation in their Factor 8 gene, and only 9% have a mutation in their Factor 9 gene. 1% of patients have a mutation in a different clotting factor gene. A doctor will make several blood tests and rule out other diseases before diagnosing Hemophilia. The diseases the doctor must rule out with similar symptoms are Von Willebrand, Dysfibrinogenemia, Hypofibrinogenemia, Thrombocytopenia, and Bernaid-Soulier Syndrome. A final blood test will determine if the person has Hemophilia, the missing factor, and the type of Hemophilia the person has. When a person is diagnosed, the mutation should be found to see if anyone else in the family carries the disorder. It is very simple to find out this information if the male has a mutation called an inversion. Almost 50% of type A patients have inversions. To test for an inversion, an DNA fingerprint must be created. There is no inversion when the fingerprint shows two very dark marks of DNA at 16.5 and 21.0 areas. But, there is an inversion when there are two dark marks at 20.0 and 17.5. If a boy has Hemophilia, the test can be used on his female blood relatives. Hemophilia was recognized in ancient times, though it wasnt named. An Arab physician by the name of Albucasis, wrote about a family whose male sons died from bleeding after minor injuries. In 1803, a physician named Dr. John Conrad Otto wrote about Hemophilia. He noticed that Hemophilia was only found in males and was a hereditary disease. The word â€Å"hemophilia† was written in a description at the University of Zurich in 1828 by Hopff. Another name for Hemophilia is â€Å"The Royal Disease†. This is because Queen Victoria carried the disease. She was the Queen of England from 1837-1901. Her son Leopold developed the disease. Leopold died from a brain hemorrhage at the age of 31, but his daughter was a carrier also. His daughter, Alice, had a male baby who also died from the disease. Two of Queen Victorias daughters carried the disease just like her. They gave the disease to the Russian, German, and Spanish royal families. Alexandra was Queen Victorias granddaughter. She married Nicholas, the Tsar of Russia in the early 1900s. Alexandra also carried the disease and passed it on to her son, the Tsarevich Alexei. You are probably thinking what its like to have this horrible disease. Males with the disease say that it is extremely painful. They talk about how they were injected as infants. A lot of their parents are very nervous and scared when they find out that their child has Hemophilia. A boy named Greg Price says that he went to summer camp with other people who have blood related diseases. He found friendship with a lot of the people who have to deal with diseases like that. He is very open with the fact that he has Hemophilia. Overall, Hemophilia is an extremely terrifying disease that no one would like to have. It may cause someone to lose their life due to a simple cut or scratch. It is extremely painful and causes people two live with a horrifying life. Hopefully, someday there will be a cure for this dreadful disease so people with the disease can live their lives with happiness, joy, and freedom.

cloning :: essays research papers

Introduction The possibility of human cloning, raised when Scottish scientists at Roslin Institute created the much-celebrated sheep "Dolly" (Nature 385, 810-13, 1997), aroused worldwide interest and concern because of its scientific and ethical implications. The feat, cited by Science magazine as the breakthrough of 1997, also generated uncertainty over the meaning of "cloning" --an umbrella term traditionally used by scientists to describe different processes for duplicating biological material. What is cloning? Are there different types of cloning? When the media report on cloning in the news, they are usually talking about only one type called reproductive cloning. There are different types of cloning however, and cloning technologies can be used for other purposes besides producing the genetic twin of another organism. A basic understanding of the different types of cloning is key to taking an informed stance on current public policy issues and making the best possible personal decisions. The following three types of cloning technologies will be discussed: (1) recombinant DNA technology or DNA cloning, (2) reproductive cloning, and (3) therapeutic cloning. Recombinant DNA Technology or DNA Cloning The terms "recombinant DNA technology," "DNA cloning," "molecular cloning,"or "gene cloning" all refer to the same process: the transfer of a DNA fragment of interest from one organism to a self-replicating genetic element such as a bacterial plasmid. The DNA of interest can then be propagated in a foreign host cell. This technology has been around since the 1970s, and it has become a common practice in molecular biology labs today. Scientists studying a particular gene often use bacterial plasmids to generate multiple copies of the same gene. Plasmids are self-replicating extra-chromosomal circular DNA molecules, distinct from the normal bacterial genome (see image to the right). Plasmids and other types of cloning vectors are used by Human Genome Project researchers to copy genes and other pieces of chromosomes to generate enough identical material for further study. To "clone a gene," a DNA fragment containing the gene of interest is isolated from chromosomal DNA using restriction enzymes and then united with a plasmid that has been cut with the same restriction enzymes. When the fragment of chromosomal DNA is joined with its cloning vector in the lab, it is called a "recombinant DNA molecule." Following introduction into suitable host cells, the recombinant DNA can then be reproduced along with the host cell DNA. See a diagram depicting this process. Plasmids can carry up to 20,000 bp of foreign DNA. cloning :: essays research papers Introduction The possibility of human cloning, raised when Scottish scientists at Roslin Institute created the much-celebrated sheep "Dolly" (Nature 385, 810-13, 1997), aroused worldwide interest and concern because of its scientific and ethical implications. The feat, cited by Science magazine as the breakthrough of 1997, also generated uncertainty over the meaning of "cloning" --an umbrella term traditionally used by scientists to describe different processes for duplicating biological material. What is cloning? Are there different types of cloning? When the media report on cloning in the news, they are usually talking about only one type called reproductive cloning. There are different types of cloning however, and cloning technologies can be used for other purposes besides producing the genetic twin of another organism. A basic understanding of the different types of cloning is key to taking an informed stance on current public policy issues and making the best possible personal decisions. The following three types of cloning technologies will be discussed: (1) recombinant DNA technology or DNA cloning, (2) reproductive cloning, and (3) therapeutic cloning. Recombinant DNA Technology or DNA Cloning The terms "recombinant DNA technology," "DNA cloning," "molecular cloning,"or "gene cloning" all refer to the same process: the transfer of a DNA fragment of interest from one organism to a self-replicating genetic element such as a bacterial plasmid. The DNA of interest can then be propagated in a foreign host cell. This technology has been around since the 1970s, and it has become a common practice in molecular biology labs today. Scientists studying a particular gene often use bacterial plasmids to generate multiple copies of the same gene. Plasmids are self-replicating extra-chromosomal circular DNA molecules, distinct from the normal bacterial genome (see image to the right). Plasmids and other types of cloning vectors are used by Human Genome Project researchers to copy genes and other pieces of chromosomes to generate enough identical material for further study. To "clone a gene," a DNA fragment containing the gene of interest is isolated from chromosomal DNA using restriction enzymes and then united with a plasmid that has been cut with the same restriction enzymes. When the fragment of chromosomal DNA is joined with its cloning vector in the lab, it is called a "recombinant DNA molecule." Following introduction into suitable host cells, the recombinant DNA can then be reproduced along with the host cell DNA. See a diagram depicting this process. Plasmids can carry up to 20,000 bp of foreign DNA.

Ethnography of Speaking Essay

The article â€Å"Ethnography of Speaking† towards a Linguistics of Praxis† by Alessandro Duranti provides thorough study of language use in everyday life of a particular speech community. Actually, the author discusses peculiarities of language use involving communicative competence, context, speech communities, speech events, speech acts and conversation analysis. This study is centered on a situation discourse meaning that linguistic performance is evaluated in terms of socio-cultural order and language. It is noted that ethnography of speaking (ES) is concerned with finding relations between â€Å"language use and local systems of knowledge and social conduct†. The author discusses the goals of the speech, attributes of linguistic code and provides definitions of main terms involved in the discussion of language use. The author admits that ethnographers of speaking are interested in analyzing language use. The author claims that â€Å"the notion of language use is strictly related to the view of sociolinguistics as merely a different methodology, a different way of obtaining data†. However, ES define language use as the use of linguistic code in terms of a particular culture or community. The author assumes that unity of language is only illusion and in order to interpret the sign it is necessary to analyze the context. The goals of ES are to establish social identities and relationships, to explain how it is possible to change the world, to provide frames for speech events and act and, finally, to break social and cultural barriers. It is necessary to notice that ethnographic study wants to describe knowledge required by participants to communicate successfully with each other. Therefore, speaking or not speaking is significant for all human interactions. The process of speaking is, thus, constitutive of reality meaning that speaking â€Å"makes something already existing present to the participants or creates something anew†. Finally, the author discusses the role of speaking in shaping people’s life. Why speaking is important for human interactions? Works Cited Duranti, Alessandro. Ethnography of Speaking Towards Linguistics of Praxis. Cambridge: Cambridge University Press.

Analysis Of The Motion Picture, Mississippi Masala, Nair (...

In this paper, a motion picture about a story of a family who was forced to move out of Uganda to the United States will be discussed. In addition, it will be presented the story a couple from two different cultures who fell in love, which brought consequences to both of their families. Also, this paper will discuss about how some people have a hard time assimilating to other cultures. In the motion picture, Mississippi Masala, Nair (1992) presents the story of a family from India who was residing in Uganda and whom was forced to leave the country because the government of that country did not want individuals from foreign heritage living in Uganda. This family was forced to move because of their heritage and skin color. In the effort to find a new life, the family sets roots in the United States, in the state of Mississippi, where their only daughter Meena fell in love with Demetrius, a self-employed African American carpet cleaner. When the family discovered that Meena and Demetriu s had fallen in love, the family members from both sides were devastated. In Meena’s case, her reputation as an Indian was being questioned, and in Demetrius case, his business was being jeopardized for falling in love with someone from a different culture. Jay, Meena’s dad decided that it was time to move back to Uganda so his daughter would not be married to a black person. However, Meena decided to stay with Demetrius, even without her parents’ consent (Nair, 1992). The motion picture,